IONIS PHARMACEUTICALS, INC.

Class 036: Providing financial information regarding patient reimbursement for pharmaceutical preparations and substances, biological preparations and substances, and therapeutic preparations and substances; Financial and insurance consultation services relating to healthcare; patient advisory, support and consultancy services regarding patient finances, insurance and financing of medical treatment; Providing financial information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; Financial and insurance consultation services relating to patient medical and pharmaceutical insurance and financing; financial advice relating to medical insurance and pharmaceutical access assisting patients and their caregivers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; Assisting patients and their caregivers to obtain authorization and payment for medical and pharmaceutical costs

Class 044: Medical and healthcare services; Providing medical information, healthcare information and information about pharmaceuticals, biologics and therapeutics; Providing healthcare and medical information regarding patient access to pharmaceuticals, biologics, and therapeutics, and safe and appropriate use and distribution of pharmaceuticals, biologics, and therapeutics; Provision of healthcare information relating to autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Patient advisory, support and consultancy services relating to healthcare, pharmaceuticals, biologics and therapeutics; Patient advisory, support and consultancy services regarding access to medical treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Providing medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Providing medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Collecting medical and clinical data and information on autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders for treatment and diagnostic purposes

Class 041: Education and training services in the field of healthcare; education and training services in the field of pharmaceuticals; education and training services in the field of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders

Class 005: Pharmaceutical preparations and substances, biological preparations and substances, therapeutic preparations and substances, namely, nucleic acid-targeted therapeutics; Pharmaceutical preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Biological preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Therapeutic preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders

Class 005: Pharmaceutical preparations and substances for the treatment of neurodevelopmental and neurodegenerative diseases and disorders, leukodystrophy, demyelinating diseases and disorders, and hypomyelinating diseases and disorders; Pharmaceutical preparations and substances for the treatment of glial fibrillary acidic protein-associated diseases and disorders, Alexander Disease, seizures, ataxia, motor function disorders, cognitive function disorders, dysphagia, and swallowing disorders; Pharmaceutical preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, neurologic, parasympathetic system, neuromuscular system, skeletomuscular system, central nervous system, epileptic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, metabolic, autoimmune and lymphoproliferative diseases and disorders; Pharmaceutical preparations containing zilganersen.; Class 044: Providing health information; providing healthcare information; medical information services provided via the Internet

Class 005: Pharmaceutical preparations and substances for the treatment of neurodevelopmental and neurodegenerative diseases and disorders, leukodystrophy, demyelinating diseases and disorders, and hypomyelinating diseases and disorders; Pharmaceutical preparations and substances for the treatment of glial fibrillary acidic protein-associated diseases and disorders, Alexander Disease, seizures, ataxia, motor function disorders, cognitive function disorders, dysphagia, and swallowing disorders; Pharmaceutical preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, neurologic, parasympathetic system, neuromuscular system, skeletomuscular system, central nervous system, epileptic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, metabolic, autoimmune and lymphoproliferative diseases and disorders; Pharmaceutical preparations containing zilganersen.; Class 044: Providing health information; providing healthcare information; medical information services provided via the Internet

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of hereditary angioedema; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; online journals, namely, blogs featuring information on hereditary angioedema; online journals, namely, blogs featuring information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; online journals, namely, blogs featuring information on hereditary angioedema and edema diseases and disorders; providing a website featuring blogs and non-downloadable publications in the nature of articles, blogs, brochures, and guides in the fields of hereditary angioedema, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Patient advisory, support and consultancy services regarding access to medical treatment of hereditary angioedema; providing healthcare information, medical information, and pharmaceutical advice online, by telephone, and through distribution of printed healthcare materials to healthcare providers, patients, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to and reimbursement for pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of hereditary angioedema and edema diseases and disorders, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of hereditary angioedema and edema diseases and disorders, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of hereditary angioedema and edema diseases and disorders, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders, and collecting data and information on hereditary angioedema, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and collecting data and information on rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and financing of medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients, their caregivers, and healthcare providers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients, their caregivers, and healthcare providers to obtain authorization and payment for medical and pharmaceutical costs; Providing pharmaceutical information regarding patient reimbursement for pharmaceuticals

Mobile healthcare services; Health care services, namely, providing support and services for disease and chronic condition management; healthcare support services

Organizing and conducting support groups in the field of healthcare; Providing emotional counseling and emotional support services for individuals

Providing on-line non-downloadable software for use in organizing, and conducting individual support groups, virtual peer matching, and providing individuals with access to healthcare and support groups; telehealth and support group videoconferencing, scheduling services, referral services, healthcare support services

Class 044: Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Class 005: Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceuticals in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceuticals in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Pharmaceutical preparations and substances in the field of neurodevelopmental and neurodegenerative diseases and disorders, leukodystrophy, demyelinating diseases and disorders, and hypomyelinating diseases and disorders; Pharmaceutical preparations and substances in the field of glial fibrillary acidic protein-associated diseases and disorders, Alexander Disease, seizures, ataxia, motor function disorders, cognitive function disorders, dysphagia, and swallowing disorders; Pharmaceutical preparations and substances in the field of autosomal dominant, autosomal recessive, genetic, neurologic, parasympathetic system, neuromuscular system, skeletomuscular system, central nervous system, epileptic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, metabolic, autoimmune and lymphoproliferative diseases and disorders; Pharmaceutical preparations containing zilganersen; Providing health information; providing healthcare information; medical information services provided via the Internet

Pharmaceutical preparations and substances in the field of neurodevelopmental and neurodegenerative diseases and disorders, leukodystrophy, demyelinating diseases and disorders, and hypomyelinating diseases and disorders; Pharmaceutical preparations and substances in the field of glial fibrillary acidic protein-associated diseases and disorders, Alexander Disease, seizures, ataxia, motor function disorders, cognitive function disorders, dysphagia, and swallowing disorders; Pharmaceutical preparations and substances in the field of autosomal dominant, autosomal recessive, genetic, neurologic, parasympathetic system, neuromuscular system, skeletomuscular system, central nervous system, epileptic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, metabolic, autoimmune and lymphoproliferative diseases and disorders; Pharmaceutical preparations containing zilganersen; Providing health information; providing healthcare information; medical information services provided via the Internet

Providing healthcare information, medical information, and pharmaceutical information online, by telephone, and through distribution of printed healthcare materials to healthcare providers, patients, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to and reimbursement for pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals; providing healthcare information; medical information services; providing a website featuring medical information in the fields of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders; medical consulting services in the fields of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders; healthcare services, namely, providing an online database comprised of medical and healthcare information in the fields of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, asthma, and rare diseases and disorders, and collecting data and information on hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders

Education and medical training services, namely, providing seminars, non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders; online journals, namely, blogs featuring information on hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders; providing a website featuring blogs and non-downloadable publications in the nature of articles, blogs, brochures, and guides in the fields of hereditary angioedema, edema, autosomal dominant, autosomal recessive, genetic, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, asthma, and rare diseases and disorders

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and access to medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients, their caregivers, and healthcare providers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients, their caregivers, and healthcare providers to obtain authorization and payment for medical and pharmaceutical costs

Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceutical preparations for the treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceuticals for treatment of genetic diseases and disorders; pharmaceuticals for treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceuticals for the treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Providing pharmaceutical information regarding patient reimbursement for pharmaceuticals; Providing healthcare information, medical information, and pharmaceutical advice online, by telephone, and through distribution of printed healthcare materials to healthcare providers, patients, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to and reimbursement for pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals; providing healthcare information; medical information services; providing a website featuring medical information regarding triglycerides, triglyceride management, familial chylomicronemia syndrome, severe hypertriglyceridemia, and pancreatitis; medical testing services, namely, providing medical quizzes and assessments via a website that are designed to provide custom tailored outputs about recommended resources and treatments associated with a defined set of symptoms and concerns; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of edema, cardiovascular, metabolic, neurological, inflammatory, respiratory, pulmonary, renal, ophthalmologic, and rare diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders; providing a website featuring blogs and non-downloadable publications in the nature of articles, blogs, brochures, and guides in the fields of triglycerides, triglyceride management, familial chylomicronemia syndrome, severe hypertriglyceridemia, and pancreatitis

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and financing of medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients, their caregivers, and healthcare providers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients, their caregivers, and healthcare providers to obtain authorization and payment for medical and pharmaceutical costs; Patient advisory, support and consultancy services regarding access to medical treatment in the nature of physician referrals; Patient advisory, support and consultancy services regarding access to medical treatment of genetic diseases and disorders; and treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders; and blood disorders

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and financing of medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients, their caregivers, and healthcare providers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients, their caregivers, and healthcare providers to obtain authorization and payment for medical and pharmaceutical costs; Patient advisory, support and consultancy services regarding access to medical treatment in the nature of physician referrals; Patient advisory, support and consultancy services regarding access to medical treatment of genetic diseases and disorders; and treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders; and blood disorders

Providing pharmaceutical information regarding patient reimbursement for pharmaceuticals; Providing healthcare information, medical information, and pharmaceutical advice online, by telephone, and through distribution of printed healthcare materials to healthcare providers, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to and reimbursement for pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals; providing healthcare information; medical information services; providing a website featuring medical information regarding triglycerides, triglyceride management, familial chylomicronemia syndrome, severe hypertriglyceridemia, and pancreatitis; medical testing services, namely, providing a website featuring medical and healthcare information for healthcare professionals, caregivers, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, and providers in the field of edema, cardiovascular, metabolic, neurological, inflammatory, respiratory, pulmonary, renal, ophthalmologic, and rare diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders; providing a website featuring blogs and non-downloadable publications in the nature of articles, blogs, brochures, and guides in the fields of triglycerides, triglyceride management, familial chylomicronemia syndrome, severe hypertriglyceridemia, and pancreatitis

Providing healthcare information, medical information, and pharmaceutical information online, by telephone, and through distribution of printed healthcare materials to patients, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to and reimbursement for pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals

Education and training services, namely, providing seminars, online non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, providing seminars, online non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of edema, cardiovascular, metabolic, neurological, inflammatory, respiratory, pulmonary, renal, ophthalmologic, and rare diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and access to medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients and their caregivers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients and their caregivers to obtain authorization and payment for medical and pharmaceutical costs

Providing pharmaceutical information regarding patient reimbursement for pharmaceuticals; Providing healthcare information, medical information, and pharmaceutical advice online, by telephone, and through distribution of printed healthcare materials to patients, physicians, medical office staff, pharmaceutical prescribers, caregivers, and pharmacies regarding patient access to pharmaceuticals and safe and appropriate use and distribution of pharmaceuticals; Patient advisory, support and consultancy services regarding access to medical treatment of autoimmune, autosomal dominant, autosomal recessive, cardiovascular, edema, gastrointestinal, genetic, inflammatory, lymphoproliferative, metabolic, neurological, ophthalmic, pulmonary, rare, renal, respiratory, and skin diseases and disorders

Financial and insurance consultation services, namely, patient advisory, support and consultancy services regarding patient finances, insurance and financing of medical treatment; providing financial and insurance information, namely, providing information and guidance in connection with health insurance benefit plans and other patient financial assistance resources; financial and insurance consultation services, namely, insurance and medical and pharmaceutical access consultation services, namely, assisting patients and their caregivers to identify the scope of coverage offered by patient medical and pharmaceutical insurance and to identify other financial assistance resources for payment of patient treatment; insurance consultation services, namely, assisting patients and their caregivers to obtain authorization and payment for medical and pharmaceutical costs; Patient advisory, support and consultancy services regarding access to medical treatment in the nature of physician referrals

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of edema, cardiovascular, metabolic, neurological, inflammatory, respiratory, pulmonary, renal, ophthalmologic, and rare diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceuticals for the treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Education and medical training services, namely, providing seminars, non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and medical training services, namely, providing seminars, non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders; Pharmaceuticals for treatment of genetic diseases and disorders; pharmaceuticals for treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders; Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceuticals for treatment of genetic diseases and disorders; pharmaceuticals for treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceutical research and development in the field of genetic diseases and disorders; providing medical and scientific research and medical and scientific research information in the field of genetic diseases and disorders; compiling data for research purposes in the field of genetic diseases and disorders; pharmaceutical research and development in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; providing medical and scientific research and medical and scientific research information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; compiling data for research purposes in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceutical research and development in the field of genetic diseases and disorders; providing medical and scientific research and medical and scientific research information in the field of genetic diseases and disorders; compiling data for research purposes in the field of genetic diseases and disorders; pharmaceutical research and development in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; providing medical and scientific research and medical and scientific research information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; compiling data for research purposes in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; medical consulting services in the field of genetic diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of genetic diseases and disorders, and collecting data and information on genetic diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of genetic diseases and disorders; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; medical consulting services in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders, and collecting data and information on cardiovascular, metabolic, neurological and inflammatory diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceuticals for treatment of genetic diseases and disorders; pharmaceuticals for treatment of cardiovascular, metabolic, neurological, and inflammatory diseases and disorders

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of genetic diseases and disorders; online journals, namely, blogs featuring information on genetic diseases and disorders; education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the field of cardiovascular, metabolic, neurological and inflammatory diseases and disorders; online journals, namely, blogs featuring information on diseases and disorders of the cardiovascular, metabolic, neurological and inflammatory diseases and disorders

Pharmaceutical preparations and substances for the treatment of edema, namely hereditary angioedema; pharmaceuticals in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Medical services; medical information services; providing a website featuring medical and healthcare information for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; medical consulting services in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; healthcare services, namely, providing an online database of medical and healthcare information in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune lymphoproliferative, and rare diseases and disorders, and collecting data and information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders for treatment and diagnostic purposes; providing medical and healthcare information concerning the screening, diagnosis, and treatment of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Pharmaceutical research and development in the field of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; providing medical and scientific research and medical and scientific research information in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; compiling data for research purposes in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Education and training services, namely, seminars, providing non-downloadable webinars, and workshops for healthcare professionals, caregivers, patients, and providers in the fields of autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders; online journals, namely, blogs featuring information on autosomal dominant, autosomal recessive, genetic, edema, pulmonary, respiratory, ophthalmic, gastrointestinal, skin, autoimmune, lymphoproliferative, and rare diseases and disorders

Diagnostic preparations and human therapeutics for medical use, namely, antisense oligonucleotides; Medical and scientific research services in the areas of medicines and pharmaceuticals for antisense therapy

Diagnostic preparations and human therapeutics for medical use, namely, antisense oligonucleotides | Medical and scientific research services in the areas of medicines and pharmaceuticals for antisense therapy

Diagnostic preparations and human therapeutics for medical use, namely, antisense oligonucleotides | Medical and scientific research services in the areas of medicines and pharmaceuticals for antisense therapy

"THERAPEUTICS"

"THERAPEUTICS"

"PHARMACEUTICALS"; medical and scientific research services in the areas of medicines and pharmaceuticals for antisense therapy

diagnostic preparations and human therapeutics for medical use, namely, antisense oligonucleotides; "PHARMACEUTICALS"

"PHARMACEUTICALS"; medical and scientific research services in the areas of medicines and pharmaceuticals for antisense therapy

Diagnostic preparations and human therapeutics for medical use, namely, antisense oligonucleotides; "PHARMACEUTICALS"

Pharmaceutical preparations and human therapeutic preparations for treating and preventing amyloidosis, genetic diseases, disorders and conditions, and protein diseases, disorders and conditions; pharmaceutical preparations and human therapeutic preparations for treating neuropathy, neurological dysfunction, and damage to nerves, tissue, organs, intestinal tract, or bone marrow; pharmaceutical preparations and human therapeutic preparations, namely, injectable antisense drugs for reducing production of transthyretin

Pharmaceutical preparations and human therapeutic preparations for treating and preventing amyloidosis, genetic diseases, disorders and conditions, and protein diseases, disorders and conditions; pharmaceutical preparations and human therapeutic preparations for treating neuropathy, neurological dysfunction, and damage to nerves, tissue, organs, intestinal tract, or bone marrow; pharmaceutical preparations and human therapeutic preparations, namely, injectable antisense drugs for reducing production of transthyretin

"THERAPEUTICS"; Drug discovery services; Laboratory research services relating to pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical research services; Providing medical and scientific research information in the fields of pharmaceuticals and genetics; Research and development in the pharmaceutical and biotechnology fields

diagnostic preparations and human therapeutics for raising HDL or the diagnosis and treatment of elevated triglycerides, pancreatitis, dyslipidemia, insulin resistance, metabolic syndrome, diabetes, familial chylomicronemia syndrome, elevated Lp(a), hypertension, inflammation, thrombosis, atherosclerosis, hypercholesterolemia, lipodystrophy, and other cardiovascular, cardiopulmonary, metabolic and inflammatory diseases and disorders; "THERAPEUTICS"

"THERAPEUTICS"; Drug discovery services; Laboratory research services relating to pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical research services; Providing medical and scientific research information in the fields of pharmaceuticals and genetics; Research and development in the pharmaceutical and biotechnology fields

diagnostic preparations and human therapeutics for raising HDL or the diagnosis and treatment of elevated triglycerides, pancreatitis, dyslipidemia, insulin resistance, metabolic syndrome, diabetes, familial chylomicronemia syndrome, elevated Lp(a), hypertension, inflammation, thrombosis, atherosclerosis, hypercholesterolemia, lipodystrophy, and other cardiovascular, cardiopulmonary, metabolic and inflammatory diseases and disorders; "THERAPEUTICS"