Theradaptive, Inc.

Class 005: Pharmaceutical and medicinal preparations and substances for the treatment and prevention of bone and tissue diseases and disorders, musculoskeletal diseases and disorders, blood vessel diseases and damage, craniomaxillofacial diseases and damage, skin diseases and damage, bone and joint injuries, spinal injuries, and cancer; Class 010: Metal parts and fittings of implantable medical devices coated with recombinant proteins; metal parts and fittings of bone regeneration matrices coated with recombinant proteins; metal parts and fittings of soft tissue regeneration matrices coated with recombinant proteins; metal parts and fittings of medical and surgical devices, apparatus, and instruments coated with recombinant proteins for use in bone, spine, and joint surgery, regeneration, reconstruction, and augmentation; metal parts and fittings of bone implants coated with recombinant proteins; Class 042: Research and development in connection with protein therapies for use in pharmaceutical products; medical research and product development in the fields of biotechnology, drug discovery, pharmaceuticals, scientific research, and protein therapeutics; development of therapeutics, namely, pharmaceutical and medical therapies for use in vascular repair, orthopedic repair, bone repair, joint repair, osteochondral repair, spinal fusion, spinal repair, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine; scientific research and development; research and development of medical devices, apparatus, and implants for use in vascular repair, orthopedic repair, bone repair, joint repair, osteochondral repair, spinal fusion, spinal repair, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine

Implants consisting of artificial materials to regenerate, repair, or treat soft tissue and bone; bone implants composed of artificial materials; implants comprising natural, non-living materials; bone regeneration matrices being artificial biomaterials for augmentation of bone for medical purposes; artificial biomaterials for augmentation of tissue for medical purposes, namely, non-living tissue substitutes for use in human tissue repair, regeneration, and reconstruction; soft tissue regeneration matrices being surgical implants and mesh made of synthetic materials for use in soft tissue repair or the reconstruction of soft tissue deficiencies; implants consisting of artificial materials; medical, surgical, and orthopedic implants made of artificial materials, namely, implantable scaffolds being fusion cages for spinal surgery and expandable spinal implants; implantable scaffolds comprising artificial materials for maintaining tissue contour; synthetic bone grafts; surgical devices, apparatus, and instruments for use in bone and joint surgery, regeneration, reconstruction, and augmentation; synthetic implantable medical devices for the regeneration of bone defects, namely, bone void fillers comprised of artificial materials; implants consisting of artificial materials for surgical repair, regeneration, reconstruction, and augmentation of human tissue; artificial bone parts to be implanted in natural bones to repair bone defects; artificial biomaterials for augmentation of bone for medical purposes, namely, synthetic materials for use in bone and joint surgery, bone regeneration, and bone reconstruction

Soft tissue regeneration matrices being surgical implants and mesh made of synthetic materials for use in soft tissue repair or the reconstruction of soft tissue deficiencies; bone implants composed of artificial materials; synthetic bone grafts; medical, surgical, and orthopedic implants made of artificial materials, namely, implantable scaffolds being fusion cages for spinal surgery and expandable spinal implants; implantable scaffolds comprising artificial materials for maintaining tissue contour; artificial bone parts to be implanted in natural bones to repair bone defects; artificial biomaterials for augmentation of bone for medical purposes, namely, synthetic materials for use in bone and joint surgery, bone regeneration, and bone reconstruction; synthetic implantable medical devices for the regeneration of bone defects, namely, bone void fillers comprised of artificial materials; implants consisting of artificial materials; implants comprising natural, non-living materials; artificial biomaterials for augmentation of tissue for medical purposes, namely, non-living tissue substitutes for use in human tissue repair, regeneration, and reconstruction; implants consisting of artificial materials to regenerate, repair, or treat soft tissue and bone; implants consisting of artificial materials for surgical repair, regeneration, reconstruction, and augmentation of human tissue; bone regeneration matrices being artificial biomaterials for augmentation of bone for medical purposes; surgical devices, apparatus, and instruments for use in bone and joint surgery, regeneration, reconstruction, and augmentation

Medical, surgical, and orthopedic implants made of artificial materials, namely, implantable scaffolds being fusion cages for spinal surgery and expandable spinal implants; synthetic implantable medical devices for the regeneration of bone defects, namely, bone void fillers comprised of artificial materials; implants consisting of artificial materials; soft tissue regeneration matrices being surgical implants and mesh made of synthetic materials for use in soft tissue repair or the reconstruction of soft tissue deficiencies; artificial biomaterials for augmentation of tissue for medical purposes, namely, non-living tissue substitutes for use in human tissue repair, regeneration, and reconstruction; artificial biomaterials for augmentation of bone for medical purposes, namely, synthetic materials for use in bone and joint surgery, bone regeneration, and bone reconstruction; bone implants composed of artificial materials; implants consisting of artificial materials to regenerate, repair, or treat soft tissue and bone; implants consisting of artificial materials for surgical repair, regeneration, reconstruction, and augmentation of human tissue; implantable scaffolds comprising artificial materials for maintaining tissue contour; bone regeneration matrices being artificial biomaterials for augmentation of bone for medical purposes; surgical devices, apparatus, and instruments for use in bone and joint surgery, regeneration, reconstruction, and augmentation; synthetic bone grafts; implants comprising natural, non-living materials

Therapeutic proteins for medical use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine; pharmaceutical and medicinal preparations and substances, namely, therapeutic proteins used for vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine; human allograft bone and tissue; Therapeutic proteins for use in the manufacture of implantable medical devices; targetable bone morphogenetic proteins for use as an inducer of regenerative bone growth media; Implantable scaffolds comprising synthetic materials for maintaining tissue contour; implants consisting of synthetic materials; synthetic bone grafts; implants comprising natural, non-living materials; implantable scaffolds comprising synthetic materials, namely, fusion cages for spinal surgery and expandable spinal implants; bone void fillers comprised of synthetic materials; bone regeneration matrices; soft tissue regeneration matrices; implantable medical devices to regenerate, repair, or treat soft tissue and bone; medical and surgical devices, apparatus, and instruments for use in bone and joint surgery, regeneration, reconstruction, and augmentation; synthetic materials for use in bone and joint surgery, bone regeneration, bone reconstruction, and bone augmentation; bone implants composed of synthetic materials; implantable synthetic materials for surgical repair, regeneration, reconstruction, and augmentation of human tissue; non-living tissue substitutes for use in human tissue repair, regeneration, reconstruction, and augmentation; synthetic implantable medical devices for the regeneration of bone defects; Research and development in connection with protein therapies for use in pharmaceutical products; medical research and product development in the fields of biotechnology, drug discovery, pharmaceuticals, scientific research, and protein therapeutics; development of therapeutics, namely, pharmaceutical and medical therapies for use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine; scientific research and development; research and development of medical devices, apparatus, and implants for use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, extremities repair, craniomaxillofacial repair, chemotherapeutics, and sports medicine

therapeutic proteins for veterinary medical use in vascular repair, orthopedic repair, bone repair, dental repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, craniomaxillofacial repair, trauma repair, immuno-oncology, orthopedic oncology, and chemotherapeutics; veterinary pharmaceutical and medicinal preparations and substances, namely, therapeutic proteins for veterinary medical purposes used for vascular repair, orthopedic repair, bone repair, dental repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, craniomaxillofacial repair, trauma repair, immuno-oncology, orthopedic oncology, and chemotherapeutics; research and development in connection with protein therapies for use in pharmaceutical products, orthopedic oncology, and immuno-oncology for veterinary medical purposes; veterinary medical research and product development in the fields of biotechnology, drug discovery, pharmaceuticals, scientific research, orthopedic oncology, immuno-oncology and protein therapeutics; development of therapeutics for veterinary purposes, namely, pharmaceutical and medical therapies for use in vascular repair, orthopedic repair, bone repair, dental repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, craniomaxillofacial repair, trauma repair, orthopedic oncology, immuno-oncology and chemotherapeutics; veterinary scientific research and development

therapeutic proteins for medical use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, immuno-oncology, orthopedic oncology, and chemotherapeutics; pharmaceutical and medicinal preparations and substances, namely, therapeutic proteins used for vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, immuno-oncology, orthopedic oncology, and chemotherapeutics; research and development in connection with protein therapies for use in pharmaceutical products orthopedic oncology, and immuno-oncology; medical research and product development in the fields of biotechnology, drug discovery, pharmaceuticals, scientific research, orthopedic oncology, immuno-oncology and protein therapeutics; development of therapeutics, namely, pharmaceutical and medical therapies for use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, orthopedic oncology, immuno-oncology and chemotherapeutics; scientific research and development

therapeutic proteins for medical use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, and chemotherapeutics; pharmaceutical and medicinal preparations and substances, namely, therapeutic proteins used for vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, and chemotherapeutics; research and development in connection with protein therapies for use in pharmaceutical products; medical research and product development in the fields of biotechnology, drug discovery, pharmaceuticals, scientific research, and protein therapeutics; development of therapeutics, namely, pharmaceutical and medical therapies for use in vascular repair, orthopedic repair, bone repair, osteochondral repair, spinal fusion, dermal repair, soft tissue repair, and chemotherapeutics; scientific research and development