CRF, Inc. logo

CRF, Inc.

37 Marks
Corp.
First Filed:Oct 14, 2005Latest Filed:Apr 4, 2017Address:4000 Chemical Road, Suite 400, Plymouth Meeting, PA 19462

Portfolio Overview

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33

Top Classes

Class 9
Electronics, Software & Scientific Equipment
27(73%)
Class 42
Software, IT Services & Scientific Research
8(22%)
Class 44
Medical, beauty and agricultural services
2(5%)

TTAB Proceedings

Total Proceedings
3
As Plaintiff
3(100%)
As Defendant
0(0%)

Top Firms

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Trademark Activity Timeline(2005 – 2017)

Trademark Portfolio

70 results

(current & previous marks)

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Filed
Registered
Last Activity
CAREHUB
CAREHUB
Service Mark
Word
ABANDONED
Owner:
Serial:87397687
Filed:Apr 4, 2017
Classes:42
STUDYIQ
STUDYIQ
Service Mark
Word
ABANDONED
Owner:
Serial:87397697
Filed:Apr 4, 2017
Classes:42
TRIALCONSENT
TRIALCONSENT
Trademark
Stylized
ABANDONED
Owner:
Serial:87071189
Filed:Jun 14, 2016
Classes:9
TRIALCONSENT
TRIALCONSENT
Trademark
Word
ABANDONED
Owner:
Serial:87014134
Filed:Apr 26, 2016
Classes:9
TRIALMAX SYNAPSE
TRIALMAX SYNAPSE
Trademark
Combined
ABANDONED
Owner:
Serial:85539751
Filed:Feb 10, 2012
Classes:9
TRIALMAX SYNAPSE
TRIALMAX SYNAPSE
Trademark
Word
ABANDONED
Owner:
Serial:85539744
Filed:Feb 10, 2012
Classes:9
TRIALMAX SLATE
TRIALMAX SLATE
Trademark
Combined
ABANDONED
Owner:
Serial:85480075
Filed:Nov 23, 2011
Classes:9
Goods & Services
"SLATE"
TRIALMAX TOUCH
TRIALMAX TOUCH
Trademark
Combined
CANCELLED
Owner:
Serial:85480094
Filed:Nov 23, 2011
Classes:9
Registration:4407664
Registered:Sep 24, 2013
Goods & Services
"TOUCH"
TRIALMAX WEB
TRIALMAX WEB
Service Mark
Combined
CANCELLED
Owner:
Serial:85480068
Filed:Nov 23, 2011
Classes:42
Registration:4407663
Registered:Sep 24, 2013
Goods & Services
"WEB"
TRIALMAX WEB
TRIALMAX WEB
Trademark
Combined
ABANDONED
Owner:
Serial:85480066
Filed:Nov 23, 2011
Classes:9
Goods & Services
"WEB"
TRIALMAX MOBILE
TRIALMAX MOBILE
Trademark
Word
ABANDONED
Owner:
Serial:85166848
Filed:Nov 2, 2010
Classes:9
Goods & Services
"MOBILE"
TRIALMAX MOBILE
TRIALMAX MOBILE
Service Mark
Word
ABANDONED
Owner:
Serial:85166844
Filed:Nov 2, 2010
Classes:42
Goods & Services
"MOBILE"
TRIALMAX SITE
TRIALMAX SITE
Service Mark
Word
ABANDONED
Owner:
Serial:85166858
Filed:Nov 2, 2010
Classes:42
Goods & Services
"SITE"
TRIALMAX SITE
TRIALMAX SITE
Trademark
Word
ABANDONED
Owner:
Serial:85166851
Filed:Nov 2, 2010
Classes:9
Goods & Services
"SITE"
TRIALMAX SLATE
TRIALMAX SLATE
Trademark
Word
ABANDONED
Owner:
Serial:85166856
Filed:Nov 2, 2010
Classes:9
Goods & Services
"SLATE"
TRIALMAX TOUCH
TRIALMAX TOUCH
Trademark
Word
CANCELLED
Owner:
Serial:85166866
Filed:Nov 2, 2010
Classes:9
Registration:4400505
Registered:Sep 10, 2013
TRIALMAX VOICE
TRIALMAX VOICE
Service Mark
Word
ABANDONED
Owner:
Serial:85166870
Filed:Nov 2, 2010
Classes:42
Goods & Services
"VOICE"
TRIALMAX VOICE
TRIALMAX VOICE
Trademark
Word
ABANDONED
Owner:
Serial:85166854
Filed:Nov 2, 2010
Classes:9
Goods & Services
"VOICE"
TRIALMAX WEB
TRIALMAX WEB
Service Mark
Word
CANCELLED
Owner:
Serial:85166846
Filed:Nov 2, 2010
Classes:42
Registration:4392671
Registered:Aug 27, 2013
Goods & Services
"WEB"
TRIALMAX WEB
TRIALMAX WEB
Trademark
Word
ABANDONED
Owner:
Serial:85166850
Filed:Nov 2, 2010
Classes:9
Goods & Services
"WEB"
TRIALMATE
TRIALMATE
Service Mark
Word
ABANDONED
Owner:
Serial:77899288
Filed:Dec 22, 2009
Classes:42
Goods & Services
Class 042: Providing on-line non-downloadable software for enabling healthcare study team participants to view questionnaires, test the questionnaire software application online, and provide instructions for improving the software design
THE EPRO SOLUTIONS COMPANY
THE EPRO SOLUTIONS COMPANY
Trademark
Word
ABANDONED
Owner:
Serial:77768876
Filed:Jun 26, 2009
Classes:9
TRIALSLATE
TRIALSLATE
Trademark
Word
ABANDONED
Owner:
Serial:77612757
Filed:Nov 12, 2008
Classes:9
TRIALLIBRARY
TRIALLIBRARY
Trademark
Word
CANCELLED
Owner:
Serial:77541270
Filed:Aug 7, 2008
Classes:9
Registration:3688241
Registered:Sep 29, 2009
C R F
C R F
Trademark
Combined
CANCELLED
Owner:
Serial:77104856
Filed:Feb 12, 2007
Classes:9
Registration:3526261
Registered:Nov 4, 2008
C R F CONNECTED ... FOR HEALTH
C R F CONNECTED ... FOR HEALTH
Trademark
Combined
ABANDONED
Owner:
Serial:77104873
Filed:Feb 12, 2007
Classes:9
C R F DELIVERING EDIARY EXCELLENCE
C R F DELIVERING EDIARY EXCELLENCE
Trademark
Combined
ABANDONED
Owner:
Serial:77104866
Filed:Feb 12, 2007
Classes:9
Goods & Services
"EDIARY"
IPROMPT
IPROMPT
Trademark
Stylized
CANCELLED
Owner:
Serial:77104925
Filed:Feb 12, 2007
Classes:9
Registration:3694318
Registered:Oct 6, 2009
Goods & Services
"IPROMPT"
IPROMPT YOUR INTELLIGENT REMINDER
IPROMPT YOUR INTELLIGENT REMINDER
Trademark
Stylized
ABANDONED
Owner:
Serial:77105105
Filed:Feb 12, 2007
Classes:9
Goods & Services
"IPROMPT"
TRIALCOLLECTOR
TRIALCOLLECTOR
Trademark
Word
CANCELLED
Owner:
Serial:77105139
Filed:Feb 12, 2007
Classes:9
Registration:3438977
Registered:Jun 3, 2008
TRIALINTEGRATOR
TRIALINTEGRATOR
Trademark
Word
CANCELLED
Owner:
Serial:77105155
Filed:Feb 12, 2007
Classes:9
Registration:3438978
Registered:Jun 3, 2008
TRIALLIBRARY
TRIALLIBRARY
Trademark
Word
ABANDONED
Owner:
Serial:77105127
Filed:Feb 12, 2007
Classes:9
TRIALMANAGER
TRIALMANAGER
Trademark
Word
CANCELLED
Owner:
Serial:77105148
Filed:Feb 12, 2007
Classes:9
Registration:3482608
Registered:Aug 5, 2008
TRIALMAX CONNECTED...FOR LIFE
TRIALMAX CONNECTED...FOR LIFE
Trademark
Combined
CANCELLED
Owner:
Serial:77104913
Filed:Feb 12, 2007
Classes:9
Registration:3421470
Registered:May 6, 2008
TRIALSTUDIO
TRIALSTUDIO
Trademark
Word
CANCELLED
Owner:
Serial:77105118
Filed:Feb 12, 2007
Classes:9
Registration:3510583
Registered:Oct 7, 2008
FITNES
FITNES
Service Mark
Word
ABANDONED
Owner:
Serial:78733853
Filed:Oct 14, 2005
Classes:44
FITNES - A SYSTEM THAT MAKES SENSE
FITNES - A SYSTEM THAT MAKES SENSE
Service Mark
Stylized
ABANDONED
Owner:
Serial:78733847
Filed:Oct 14, 2005
Classes:44
CAREMAX
CAREMAX
Trademark
Word
Previous
ABANDONED
Owner:
Serial:87397715
Filed:Apr 4, 2017
Classes:10
TRIALCONSENT
TRIALCONSENT
Service Mark
Stylized
Previous
CANCELLED
Owner:
Serial:87071193
Filed:Jun 14, 2016
Classes:42
Registration:5325966
Registered:Oct 31, 2017
TRIALCONSENT
TRIALCONSENT
Service Mark
Word
Previous
REGISTERED
Owner:
Serial:87014116
Filed:Apr 26, 2016
Classes:42
Registration:5325949
Registered:Oct 31, 2017
Goods & Services
Software as a service (SAAS) services featuring software for enabling patients to enroll in a clinical study
CRF HEALTH
CRF HEALTH
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:86966251
Filed:Apr 6, 2016
Classes:9
Registration:5633293
Registered:Dec 18, 2018
Goods & Services
Software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Computer software for enabling the capture, reporting, and processing of clinical outcomes assessments in pharmaceutical industry clinical trials; Downloadable mobile applications for facilitating the generation of patient reported outcomes in pharmaceutical industry clinical trials; Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices; Downloadable computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices; Computer software for conveying to patients information related to a clinical trial using interactive multimedia and for enabling patients to dynamically engage, review, question and agree to participate in a clinical trial, featuring tiered information delivery, interactive assessments, interactive communication of questions to the clinical trial staff, and to generate information and reports, and featuring a development platform allowing users to collaboratively design and develop content across multiple stakeholders; "HEALTH"
CRF HEALTH
CRF HEALTH
Trademark
Word
Previous
CANCELLED
Owner:
Serial:86966241
Filed:Apr 6, 2016
Classes:9
Registration:5633291
Registered:Dec 18, 2018
Goods & Services
Software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Computer software for enabling the capture, reporting, and processing of clinical outcomes assessments in pharmaceutical industry clinical trials; Downloadable mobile applications for facilitating the generation of patient reported outcomes in pharmaceutical industry clinical trials; Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices; Downloadable computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices; Computer software for conveying to patients information related to a clinical trial using interactive multimedia and for enabling patients to dynamically engage, review, question and agree to participate in a clinical trial, featuring tiered information delivery, interactive assessments, interactive communication of questions to the clinical trial staff, and to generate information and reports, and featuring a development platform allowing users to collaboratively design and develop content across multiple stakeholders; "HEALTH"
CRF HEALTH
CRF HEALTH
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:86966246
Filed:Apr 6, 2016
Classes:42
Registration:5633292
Registered:Dec 18, 2018
Goods & Services
"HEALTH"; Software as a service (SAAS) services featuring software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on web based, short message service, and mobile devices; Software as a service (SAAS) services featuring software for interfacing and integrating with third party clinical systems to enable transferring, collecting, viewing, and sharing of clinical study data; Software as a service (SAAS) services featuring software for conveying to patients information related to a clinical trial using interactive multimedia and for enabling patients to dynamically engage, review, question and agree to participate in a clinical trial, featuring tiered information delivery, interactive assessments, interactive communication of questions to the clinical trial staff, and to generate information and reports, and featuring a development platform allowing users to collaboratively design and develop content across multiple stakeholders
CRF HEALTH
CRF HEALTH
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:86966254
Filed:Apr 6, 2016
Classes:42
Registration:5633294
Registered:Dec 18, 2018
Goods & Services
"HEALTH"; Software as a service (SAAS) services featuring software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on web based, short message service, and mobile devices; Software as a service (SAAS) services featuring software for interfacing and integrating with third party clinical systems to enable transferring, collecting, viewing, and sharing of clinical study data; Software as a service (SAAS) services featuring software for conveying to patients information related to a clinical trial using interactive multimedia and for enabling patients to dynamically engage, review, question and agree to participate in a clinical trial, featuring tiered information delivery, interactive assessments, interactive communication of questions to the clinical trial staff, and to generate information and reports, and featuring a development platform allowing users to collaboratively design and develop content across multiple stakeholders
TRIALMANAGER
TRIALMANAGER
Service Mark
Stylized
Previous
REGISTERED
Owner:
Serial:86959988
Filed:Mar 31, 2016
Classes:42
Registration:5221027
Registered:Jun 13, 2017
Goods & Services
Software as a service (SAAS) services featuring software for enabling users to view, manage and report on patient-reported data in pharmaceutical industry clinical trials
TRIALMANAGER
TRIALMANAGER
Service Mark
Word
Previous
REGISTERED
Owner:
Serial:86959993
Filed:Mar 31, 2016
Classes:42
Registration:5221028
Registered:Jun 13, 2017
Goods & Services
Software as a service (SAAS) services featuring software for enabling users to view, manage and report on patient-reported data in pharmaceutical industry clinical trials
TRIALMAX SLATE
TRIALMAX SLATE
Trademark
Word
Previous
REGISTERED
Owner:
Serial:86959998
Filed:Mar 31, 2016
Classes:9
Registration:5085877
Registered:Nov 22, 2016
Goods & Services
Class 009: Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes; Downloadable computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes
TRIALMAX SLATE
TRIALMAX SLATE
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:86959996
Filed:Mar 31, 2016
Classes:9
Registration:5085876
Registered:Nov 22, 2016
Goods & Services
"SLATE"
TRIALSTUDIO
TRIALSTUDIO
Service Mark
Word
Previous
REGISTERED
Owner:
Serial:86959982
Filed:Mar 31, 2016
Classes:42
Registration:5617838
Registered:Nov 27, 2018
Goods & Services
Software as a service (SAAS) services featuring software for the development, design, localization and simulation of electronic clinical outcome assessments for pharmaceutical industry clinical trials
TRIALSTUDIO
TRIALSTUDIO
Service Mark
Stylized
Previous
CANCELLED
Owner:
Serial:86959975
Filed:Mar 31, 2016
Classes:42
Registration:5633284
Registered:Dec 18, 2018
Goods & Services
Software as a service (SAAS) services featuring software for the development, design, localization and simulation of electronic clinical outcome assessments for pharmaceutical industry clinical trials
CRF HEALTH SIMPLY RELIABLE
CRF HEALTH SIMPLY RELIABLE
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:86782409
Filed:Oct 8, 2015
Classes:42
Registration:5115638
Registered:Jan 3, 2017
Goods & Services
"HEALTH"
CRF HEALTH SIMPLY RELIABLE
CRF HEALTH SIMPLY RELIABLE
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:86782411
Filed:Oct 8, 2015
Classes:9
Registration:5115639
Registered:Jan 3, 2017
Goods & Services
"HEALTH"
SIMPLY RELIABLE
SIMPLY RELIABLE
Trademark
Word
Previous
CANCELLED
Owner:
Serial:86691327
Filed:Jul 13, 2015
Classes:9
Registration:5692011
Registered:Mar 5, 2019
Goods & Services
Software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Computer software for enabling the capture, reporting, and processing of clinical outcomes assessments in pharmaceutical industry clinical trials; Downloadable mobile applications for facilitating the generation of patient reported outcomes in pharmaceutical industry clinical trials; Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices; Downloadable computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on mobile computing devices
SIMPLY RELIABLE
SIMPLY RELIABLE
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:86691329
Filed:Jul 13, 2015
Classes:42
Registration:5692012
Registered:Mar 5, 2019
Goods & Services
Software as a service (SAAS) services featuring software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of clinical outcomes assessments on web based, short message service, and mobile devices; Software as a service (SAAS) services featuring software for interfacing and integrating with third party clinical systems to enable transferring, collecting, viewing, and sharing of clinical study data
TRIALMAX CONMED
TRIALMAX CONMED
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:86691321
Filed:Jul 13, 2015
Classes:9
Registration:5692009
Registered:Mar 5, 2019
Goods & Services
Software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications
TRIALMAX CONMED
TRIALMAX CONMED
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:86691319
Filed:Jul 13, 2015
Classes:42
Registration:5692008
Registered:Mar 5, 2019
Goods & Services
Software as a service (SAAS) services featuring software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications
TRIALMAX CONMED
TRIALMAX CONMED
Trademark
Word
Previous
CANCELLED
Owner:
Serial:86691314
Filed:Jul 13, 2015
Classes:9
Registration:5697606
Registered:Mar 12, 2019
Goods & Services
Software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications
TRIALMAX CONMED
TRIALMAX CONMED
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:86691324
Filed:Jul 13, 2015
Classes:42
Registration:5692010
Registered:Mar 5, 2019
Goods & Services
Software as a service (SAAS) services featuring software for enabling patients to select a medication from a list of their frequent medications, select a new drug or therapy, and enter all medication intake, all of which information is added to existing study questionnaires as a way to record concomitant medications
TRIALMAX APP
TRIALMAX APP
Trademark
Word
Previous
REGISTERED
Owner:
Serial:86591244
Filed:Apr 8, 2015
Classes:9
Registration:4855180
Registered:Nov 17, 2015
Goods & Services
Class 009: Downloadable mobile applications for use in pharmaceutical industry clinical trials to facilitate the generation of patient reported outcomes
TRIALMAX APP
TRIALMAX APP
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:86458651
Filed:Nov 19, 2014
Classes:9
Registration:4772713
Registered:Jul 14, 2015
Goods & Services
"APP"
TRIALMAX SYNAPSE
TRIALMAX SYNAPSE
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:85539750
Filed:Feb 10, 2012
Classes:42
Registration:4808778
Registered:Sep 8, 2015
TRIALMAX SYNAPSE
TRIALMAX SYNAPSE
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:85539756
Filed:Feb 10, 2012
Classes:42
Registration:4808779
Registered:Sep 8, 2015
TRIALMAX SLATE
TRIALMAX SLATE
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:85480076
Filed:Nov 23, 2011
Classes:42
Registration:4605863
Registered:Sep 16, 2014
Goods & Services
"SLATE"; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes
TRIALMAX TOUCH
TRIALMAX TOUCH
Service Mark
Combined
Previous
CANCELLED
Owner:
Serial:85480099
Filed:Nov 23, 2011
Classes:42
Registration:4605864
Registered:Sep 16, 2014
Goods & Services
"TOUCH"; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes on handhelds and PDAs
TRIALMAX SLATE
TRIALMAX SLATE
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:85166861
Filed:Nov 2, 2010
Classes:42
Registration:4589022
Registered:Aug 19, 2014
Goods & Services
"SLATE"; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes
TRIALMAX TOUCH
TRIALMAX TOUCH
Service Mark
Word
Previous
CANCELLED
Owner:
Serial:85166863
Filed:Nov 2, 2010
Classes:42
Registration:4593141
Registered:Aug 26, 2014
Goods & Services
"TOUCH"; Software as a service (SAAS) services featuring software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of patient reported outcomes on handhelds and PDAs
C-R-F HEALTH REAL PATIENT DATA 24/7
C-R-F HEALTH REAL PATIENT DATA 24/7
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:77964080
Filed:Mar 20, 2010
Classes:9
Registration:4533812
Registered:May 20, 2014
Goods & Services
Class 009: Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of data and information
CRF HEALTH
CRF HEALTH
Trademark
Word
Previous
REGISTERED
Owner:
Serial:77768877
Filed:Jun 26, 2009
Classes:9
Registration:3953087
Registered:May 3, 2011
Goods & Services
Class 009: Computer software for the collection, editing, organizing, modifying, book marking, transmission, storage and sharing of data and information
CRF HEALTH
CRF HEALTH
Trademark
Combined
Previous
CANCELLED
Owner:
Serial:77769117
Filed:Jun 26, 2009
Classes:9
Registration:3956447
Registered:May 10, 2011
Goods & Services
"HEALTH"
TRIALMAX
TRIALMAX
Trademark
Word
Previous
REGISTERED
Owner:
Serial:76515515
Filed:May 19, 2003
Classes:9
Registration:3114603
Registered:Jul 11, 2006
Goods & Services
Computer software used to enable the capture, reporting, and processing of data in pharmaceutical industry clinical trials