NATURE'S TOOLBOX, INC.

Production of RNA for others; Production of conventional mRNA and self-amplifying RNA for others; Customized in vitro transcription (IVT) and purification of RNA for others; Customized in vitro transcription (IVT) of conventional mRNA and self-amplifying RNA for others; Custom design of RNA and modified RNA for in vitro synthesis; Custom in vitro synthesis of RNA and modified RNA; and Custom design of DNA for use in in vitro transcription (IVT) systems; Laboratory device for the production of RNA; Continuous flow in vitro transcription (IVT) device utilizing a hollow-fiber bioreactor for RNA synthesis; Continuous flow in vitro transcription (IVT) device for RNA production and purification; Modular in vitro transcription (IVT) device for production and purification of conventional mRNA and self-amplifying RNA; Self-contained modular inserts containing enzymes and chemicals for in vitro transcription of RNA and modified RNA; and Reagent kits including enzymes and chemicals for in vitro transcription of RNA and modified RNA

Enzymes and reagents for synthesis of RNA and proteins; Enzymes and reagents for vitro transcription of RNA; Enzymes and reagents for vitro translation of proteins; Enzymes and reagents for purification of RNA and proteins; Chemicals and reagents for the production of lipid-nanoparticles (LNPs); Enzymes derived from biotechnological processes for use in industry; Reagents and enzymes for scientific and research use; Kits containing enzymes and reagents for synthesis of RNA and proteins; Kits containing enzymes and reagents for vitro transcription of RNA and proteins; Kits containing enzymes and reagents for vitro translation proteins; Kits containing chemicals and reagents for purification of RNA and proteins; Kits containing chemicals and reagents for the production of lipid-nanoparticles (LNPs); and Pseudouridine; Reagent kits including chemicals and reagents for encapsulating RNA in LNPs; Chemicals and reagents for encapsulating RNA in LNPs

Laboratory device for the production of proteins; Continuous flow in vitro translation (IVT) device utilizing a hollow-fiber bioreactor for protein synthesis; Continuous flow in vitro translation (IVT) device for production and purification of proteins; Modular in vitro translation (IVT) device for production and purification of proteins; Self-contained modular inserts containing enzymes and chemicals for in vitro translation of proteins; and Reagent kits including enzymes and chemicals for in vitro translation of proteins

In vitro transcription (IVT) device utilizing a hollow-fiber bioreactor for RNA synthesis; Continuous flow IVT device for RNA production and purification; Modular IVT device for production and purification of conventional mRNA and self-amplifying RNA; Modular IVT device for encapsulating purified conventional mRNA and self-amplifying RNA in a lipid nano-particle (LNP); Self-contained modular inserts containing enzymes and chemicals for in vitro transcription and purification of RNA; Self-contained modular inserts for producing and for encapsulating RNA in LNPs; Self-contained modular inserts containing enzymes and chemicals for isothermal amplification of RNA; Reagent kits including enzymes and chemicals for in vitro transcription of RNA; Reagent kits including enzymes and chemicals for purification of RNA; Reagent kits including chemicals and reagents for encapsulating RNA in LNPs; Reagent kits including enzymes and chemicals for isothermal amplification of RNA

In vitro transcription (IVT) device utilizing a hollow-fiber bioreactor for RNA synthesis; Continuous flow IVT device for RNA production and purification; Modular IVT device for production and purification of conventional mRNA and self-amplifying RNA; Modular IVT device for encapsulating purified conventional mRNA and self-amplifying RNA in a lipid nano-particle (LNP); Self-contained modular inserts containing enzymes and chemicals for in vitro transcription and purification of RNA; Self-contained modular inserts for producing and for encapsulating RNA in LNPs; Self-contained modular inserts containing enzymes and chemicals for isothermal amplification of RNA; Reagent kits including enzymes and chemicals for in vitro transcription of RNA; Reagent kits including enzymes and chemicals for purification of RNA; Reagent kits including chemicals and reagents for encapsulating RNA in LNPs; Reagent kits including enzymes and chemicals for isothermal amplification of RNA

Research and development of pharmaceuticals, therapeutics, and biologics for the treatment of viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development of biosynthetic pathways involved in response to viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development of biosynthetic pathways and their evolution in response to viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development in the field of bioinformatics-derived drug discovery; Research and development of software-based platforms for the identification of novel therapeutic drug compounds, namely, software-based platforms for collecting, identifying, and searching collections of natural products and/or biosynthesis pathways and generating a drug compound database that allows for structure guided searching to identify new therapeutic drug candidates; Medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics

Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, acellular vaccines, protein-based vaccines, conjugated vaccines, and vaccines generated in an in vitro cell-free expression system; Research and development in the field of bioinformatics and production of proteins in cell-free expression systems for the development of vaccines; Medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use, namely, new vaccines for therapeutic use

Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, antibiotics, vaccines generated in a cell-free protein synthesizing system, antibiotics generated in a cell-free protein synthesizing system, proteins generated in a cell-free protein synthesizing system, and enzymes generated in a cell-free protein synthesizing system; research and development in the field of bioinformatics and production of proteins in cell-free systems for the development of vaccines, and antibiotics; medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use; research and development of new biological products for therapeutic use; research and development of antibiotic compounds for therapeutic use; research and development of methods of high-throughput screening of biological materials; research and development of methods of rapid-prototyping of biological materials; research and development of methods of real-time metabolic profiling of bacteria, fungi and plants to discover, characterize and produce bioactive products; design and development of nucleic acids, proteins, enzymes, antibiotic compounds, and drug compounds for use in pharmaceuticals, biotechnology, and medical and diagnostic applications using predictive bioinformatics; bioinformatics scientific research services, namely, identifying new drug compounds from analysis of genomic data

Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines and therapeutics, and RNA vaccines and therapeutics; Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines and therapeutics, and RNA vaccines and therapeutics generated a cell-free expression system; Research and development of RNA production systems

Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, acellular vaccines, protein-based vaccines, conjugated vaccines, and vaccines generated in an in vitro cell-free expression system; Research and development in the field of bioinformatics and production of proteins in cell-free expression systems for the development of vaccines; Medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use, namely, new vaccines for therapeutic use; Research and development of pharmaceuticals, therapeutics, and biologics for the treatment of viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development in the field of biosynthetic pathways involved in response to viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development in the field of biosynthetic pathways and their evolution in response to viral infection, bacterial infection, fungal infection, and parasitic infestation; Research and development in the fields of bioinformatic-derived drug discovery; Research and development of software-based platforms for the identification of novel therapeutic drug compounds, namely, software-based platforms for collecting, identifying, and searching collections of natural products and biosynthesis pathways and generating a drug compound database that allows for structure guided searching to identify new therapeutic drug candidates; Services in the field of therapeutic drug discovery, namely, providing temporary use of online non-downloadable data processing software services, in the fields of pharmaceutical, biomedical, medical and clinical research and drug discovery; Services in the field of therapeutic drug discovery, namely, providing temporary use of online non-downloadable software services for the identification of novel therapeutic drug compounds, namely, providing temporary use of online non-downloadable software services for collecting, identifying, and searching collections of the biosynthetic pathways and their products and generating a drug compound database that allows for structure guided searching to identify new therapeutic drug candidates; Research and development of pharmaceuticals, therapeutics, and biologics, namely, toxins for therapeutic use, protein- based toxins for therapeutic use, protein-based toxins generated in an in vitro cell-free expression system for therapeutic and medical research uses; Research and development in the field of bioinformatics and production of protein-based toxins having therapeutic applications; Research and development of new toxin compounds for therapeutic use, namely, new protein-based toxins for therapeutic use; Research and development of pharmaceuticals, therapeutics, and biologics, namely, toxins for diagnostic use, protein-based toxins for diagnostic use, protein-based toxins generated in an in vitro cell-free expression system for diagnostic and medical research uses

Custom manufacturer of pharmaceutical and biopharmaceutical compounds, namely, antibiotics, proteins, vaccines, enzymes, and small molecules; "TOOLBOX"; Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, antibiotics, vaccines generated in a cell-free protein synthesizing system, antibiotics generated in a cell-free protein synthesizing system, proteins generated in a cell-free protein synthesizing system, and enzymes generated in a cell-free protein synthesizing system; research and development in the field of bioinformatics and production of proteins in cell-free systems for the development of vaccines, and antibiotics; medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use; research and development of new biological products for therapeutic use; research and development of antibiotic compounds for therapeutic use; research and development of methods of high-throughput screening of biological materials; research and development of methods of rapid-prototyping of biological materials; research and development of methods of real-time metabolic profiling of bacteria, fungi and plants to discover, characterize and produce bioactive products; design and development of nucleic acids, proteins, enzymes, antibiotic compounds, and drug compounds for use in pharmaceuticals, biotechnology, and medical and diagnostic applications using predictive bioinformatics; bioinformatics scientific research services, namely, identifying new drug compounds from analysis of genomic data

Custom manufacturer of pharmaceutical and biopharmaceutical compounds, namely, antibiotics, proteins, vaccines, enzymes, and small molecules; Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, antibiotics, vaccines generated in a cell-free protein synthesizing system, antibiotics generated in a cell-free protein synthesizing system, proteins generated in a cell-free protein synthesizing system, and enzymes generated in a cell-free protein synthesizing system; research and development in the field of bioinformatics and production of proteins in cell-free systems for the development of vaccines, and antibiotics; medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use; research and development of new biological products for therapeutic use; research and development of antibiotic compounds for therapeutic use; research and development of methods of high-throughput screening of biological materials; research and development of methods of rapid-prototyping of biological materials; research and development of methods of real-time metabolic profiling of bacteria, fungi and plants to discover, characterize and produce bioactive products; design and development of nucleic acids, proteins, enzymes, antibiotic compounds, and drug compounds for use in pharmaceuticals, biotechnology, and medical and diagnostic applications using predictive bioinformatics; bioinformatics scientific research services, namely, identifying new drug compounds from analysis of genomic data

Custom manufacturer of pharmaceutical and biopharmaceutical compounds, namely, antibiotics, proteins, vaccines, enzymes, and small molecules; Research and development of pharmaceuticals, therapeutics, and biologics, namely, vaccines, antibiotics, vaccines generated in a cell-free protein synthesizing system, antibiotics generated in a cell-free protein synthesizing system, proteins generated in a cell-free protein synthesizing system, and enzymes generated in a cell-free protein synthesizing system; research and development in the field of bioinformatics and production of proteins in cell-free systems for the development of vaccines, and antibiotics; medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; research and development of new drug compounds for therapeutic use; research and development of new biological products for therapeutic use; research and development of antibiotic compounds for therapeutic use; research and development of methods of high-throughput screening of biological materials; research and development of methods of rapid-prototyping of biological materials; research and development of methods of real-time metabolic profiling of bacteria, fungi and plants to discover, characterize and produce bioactive products; design and development of nucleic acids, proteins, enzymes, antibiotic compounds, and drug compounds for use in pharmaceuticals, biotechnology, and medical and diagnostic applications using predictive bioinformatics; bioinformatics scientific research services, namely, identifying new drug compounds from analysis of genomic data

Research and development of pharmaceuticals, therapeutics, and biologics, namely, toxins for therapeutic use, protein-based toxins for therapeutic use, protein-based toxins generated in an in vitro cell-free expression system for therapeutic and medical research uses; Research and development in the field of bioinformatics and production of protein-based toxins having therapeutic applications; Medical research and development in the field of synthetic biology, molecular biology, genetic engineering and bioinformatics; Research and development of new toxin compounds for therapeutic use, namely, new protein-based toxins for therapeutic use; Research and development of pharmaceuticals, therapeutics, and biologics, namely, toxins for diagnostic use, protein-based toxins for diagnostic use, protein-based toxins generated in an in vitro cell-free expression system for diagnostic and medical research uses